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KMID : 0043319990220050520
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Archives of Pharmacal Research
1999 Volume.22 No. 5 p.520 ~ p.523
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HIV Integrase Inhibitory Activity of Agastache regosa
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Kim Hye-Kyung
Lee Hyeong-Kyu
Shin Cha-Gyun
Huh Hoon
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Abstract
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We have been screening anti-HIV integrase compounds from Korean medicinal plants by using an in vitro assay system which is mainly composed of recombinant human immunodeficency virus type 1 integrase and radiolabeled oligonucleotides. From the above screening, the aqueous methanolic extract of the roots of Agastache rugosa exhibited a significant activity. Bioactivity-guided chromatographic fractionation of the methanolic extract resulted in the isolation of rosmarinic acid. The structure of the compound was determined by spectroscopic data and by the comparison with the reported values. The of the rosmarinic acid was approximately against HIV integrase.
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KEYWORD
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HIV integrase, Agastache rugosa, Labiatae, Rosmarinic acid
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